Kalshi Wants to Let People Bet on Whether Clinical Trials Will Work

Photo Credit: Joe Flood (CC BY-NC 4.0).

Medical experts are concerned about gambling “prediction market” company Kalshi’s decision to let people wager on the approval of medical treatments.

“Prediction market” companies like Kalshi and Polymarket exploit loopholes in state and federal law to bring casino-style gambling to anyone with a smartphone. While traditional gambling operates under state oversight and state law, prediction market platforms claim protection under federal commodities laws, letting people wager hundreds of millions of dollars on sports, elections, and other events without being accountable to state regulators. Some of these companies have been accused of using deceptive videos and fake wins to appeal to young people on social media. Others have been taken to court for refusing to abide by state gambling and consumer protection laws.

In July, the online “prediction market” platform Kalshi announced it would host betting on the outcomes of clinical trials and U.S. Food and Drug Administration (FDA) regulatory reviews. A recent column published in the Journal of the American Medical Association (JAMA) is raising serious ethical concerns about what that means for medical research and for patients.

Among other things, authors at JAMA believe the odds that platforms like Kalshi assign to clinical trials could affect whether people pursue experimental treatments, writing:

“The effects on trial participants touch the ethical core of the relationship between investigator and participant. Low public odds of success could discourage continued participation in trials that already carries high participant burden, increasing dropout and reducing statistical power. High public odds could have the opposite effect: participants who do not perceive the benefit predicted by optimistic markets may conclude they are in the placebo group and discontinue follow-up. When they enroll, participants accept trial-related risk in exchange for the resulting data’s validity and value to society. Trial participation is fundamentally altruistic, and public markets that negatively impact retention and reporting, and therefore validity, ultimately subvert that altruism.”

The authors also note that Kalshi does not do enough to prevent people from unjustly enriching themselves through “prediction market” wagers on medical trials:

“In securities markets, insider-trading restrictions prevent individuals with access to material nonpublic information from unfairly profiting from that access. Strict controls limit access to information that could impact a company’s share price, trading is tightly regulated and monitored, and trades by corporate officers with potential material information are publicly disclosed. No such framework exists for clinical trials prediction markets. Kalshi’s proposed safeguards are inadequate to guard against these possibilities, and are the regulatory equivalent of corporations setting their own rules against insider trading.”

To put it another way, how would you feel if you knew someone on your medical team was secretly wagering on Kalshi that your medical treatments would not work?

This is simply another example of how deeply troubling prediction markets can be. As powerful corporations try to make gambling part of everyday life, it’s important for Arkansas to protect its citizens and families from predatory gambling. Otherwise gambling will simply continue wrecking lives and hurting families in our state.

Articles appearing on this website are written with the aid of Family Council’s researchers and writers.

Gambling Supporters Bet Big on Arkansas Candidates

Advocates for the gambling industry have donated more than $100,000 to political campaigns in Arkansas since the beginning of 2025.

Three casinos are currently licensed to operate in Arkansas, and policymakers have authorized mobile sports betting in the state — which is now a multimillion-dollar industry by itself.

But financial data from the Arkansas Secretary of State shows trade associations and companies that advocate for casinos, tribal gaming, and other forms of gambling have donated a substantial amount of money to candidates and political action committees in the state.

Candidate/CommitteeTransaction AmountTransaction DateContributorContributor Address
Team SHS (Sarah Huckabee Sanders) PAC$2,500.0005/01/2025American Gaming Association799 9th St. NW, Suite 700, Washington, DC, 20001
Brown, Karilyn$1,000.0010/05/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Gonzales, Justin$3,500.0009/30/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Rogers, Cody$500.0008/21/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Underwood, Kendon$500.0008/21/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
McAlindon, Melinda Mindy””$750.0008/20/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Brown, Karilyn$2,000.0008/20/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Brown, Matthew$500.0006/16/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Brown, Karilyn$500.0006/08/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Gramlich, Zachary$3,500.0004/02/2026Choctaw Nation House PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
ACHOR, BRANDON$3,500.0009/30/2026Choctaw Nation Senate PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Moore, William$1,000.0009/17/2026Choctaw Nation Senate PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Boyd, Phillip Justin””$3,500.0004/02/2026Choctaw Nation Senate PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Simon, Brad$1,000.0002/18/2026Choctaw Nation Senate PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Boyd, Phillip Justin””$500.0008/18/2026Choctaw Nation Statewide PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Gramlich, Zachary$500.0008/18/2026Choctaw Nation Statewide PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Boyd, Phillip Justin””$1,590.2804/02/2026Choctaw Nation Statewide PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Gramlich, Zachary$1,590.2804/02/2026Choctaw Nation Statewide PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Sanders, Sarah$3,500.0004/02/2026Choctaw Nation Statewide PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Hammer, Kim$1,000.0002/23/2026Choctaw Nation Statewide PAC1301 W. Capitol Avenue, Little Rock, AR, 72201
Jobs and Growth PAC$10,000.0003/05/2025FanDuel Inc.300 Park Avenue South 14th Floor, New York, NY, 10010
Pillar Leadership PAC$5,000.0009/25/2026Kalshi594 Broadway, Suite 407, New York, NY, 10012
Build Strengthen & Empower PAC$5,000.0009/28/2026Kalshi, Inc594 Broadway Street, Suite 407, New York, NY, 10012
Team SHS (Sarah Huckabee Sanders) PAC$10,000.0009/21/2026Kalshi, Inc.594 Broadway, Ste. 407, New York, NY, 10012
House Leadership PAC$10,000.0008/28/2026Oaklawn Jockey Club226 Meremac Avenue, St Loius, MO, 63105
Build Strengthen & Empower PAC$5,000.0009/29/2025Oaklawn Jockey Club2705 Central Avenue, Hot Springs, AR, 71902
REPUBLICAN PARTY OF ARKANSAS(STATE)$2,500.0002/24/2025OAKLAWN JOCKEY CLUB INC225 S MERAMEC AVE, ST LOUIS, MO, 63105
Arkansas Wins PAC$10,000.0006/01/2026Saracen Casino Resort1 Saracen Resort Drive, Pine Bluff, AR, 71601
REPUBLICAN PARTY OF ARKANSAS(STATE)$2,500.0002/24/2025SARACEN CASINO RESORT1 Saracen Resort Dr, Pine Bluff, AR, 71601
Arkansas State Chamber of Commerce PAC$2,500.0012/11/2025SOUTHLAND PARK GAMING & RACING1550 N. Ingram Blvd. , West Memphis, AR, 72301
Jobs and Growth PAC$6,600.0003/13/2025Underdog Sports Holdings, Inc.150 Waterbury St., Brooklyn, NY, 11206
Total$102,030.56

Powerful corporations are working very hard to normalize gambling in America and influence policymakers — but modern gambling is raising serious concerns.

“Prediction market” gambling companies have been accused of using deceptive videos and fake wins to appeal to young people on social media. Some have been taken to court for refusing to abide by state gambling and consumer protection laws.

Experts have repeatedly voiced concerns about gambling ads that aggressively target young adults. A report from Common Sense Media found that among boys exposed to gambling content online, 59% said the content appeared in their feeds without them looking for it.

Research published this summer found gambling disorder diagnoses have risen more than 60% in states that legalized sports betting.

Gambling is not a harmless pastime. As powerful corporations try to make gambling part of everyday life, it’s important for Arkansas to protect citizens and families from predatory gambling. Otherwise, problem gambling will simply hurt more and more people in our state.

Articles appearing on this website are written with the aid of Family Council’s researchers and writers.

“Prediction Markets” Pile Up Political Donations Ahead of Midterms

Les Bernal, National Director of Stop Predatory Gambling, recently appeared on Washington Watch, where he discussed a concerning uptick in political donations from so-called “prediction market” platforms.

“Prediction markets” are companies that exploit loopholes in state and federal law to bring casino-style gambling to anyone with a smartphone. While traditional gambling operates under state oversight and state law, prediction market platforms claim protection under federal commodities laws, letting people wager hundreds of millions of dollars on sports, elections, and other events without being accountable to state regulators.

Now news outlets report that prediction market platforms are donating millions of dollars to candidates ahead of the November midterm elections.

During his appearance on Washington Watch, Bernal said these gambling companies are “spending relentlessly” on political contributions in hopes that legislators will “look the other way” when it comes to the harm that their companies inflict:

“Prediction markets especially represent a con. This is a form of consumer financial fraud that’s only legal when you partner with the government. So for Kalshi and Polymarket and these other companies, the only way their business model survives is by partnering with these with public officials and getting their approval, and so what they’re hoping to do, whether it’s through the Democrats or Republicans – and Republicans frankly are just as bad on this issue as the Democrats are – is they use this so-called dark money to run their campaigns. But ultimately it buys these companies major influence behind the scenes to perpetuate a product in these prediction markets as well as these other forms of online gambling. They’re inflicting life-changing harm on tens of millions of Americans.”

So far this year, “prediction market” company Kalshi has donated a total of $20,000 to three different political action committees in Arkansas. Political action committees — or PACs — typically work to elect or defeat candidates for public office. The money that a PAC raises from “prediction markets” can be given to another candidate’s campaign or the PAC can use it to run its own campaign ads for or against candidates.

ContributorContributor AddressCandidate or CommitteeTransaction AmountTransaction Date
Kalshi, Inc594 Broadway Street, Suite 407, New York, NY, 10012Build Strengthen & Empower PAC$5,00009/28/2026
Kalshi594 Broadway, Suite 407, New York, NY, 10012Pillar Leadership PAC$5,00009/25/2026
Kalshi, Inc.594 Broadway, Ste. 407, New York, NY, 10012Team SHS (Sarah Huckabee Sanders) PAC$10,00009/21/2026

We have written before about how prediction markets are deeply troubling. Some of these companies have been accused of using deceptive videos and fake wins to appeal to young people on social media. Others have been taken to court for refusing to abide by state gambling and consumer protection laws.

This kind of predatory gambling destroys families. Internet gambling is ruining lives, and prediction markets are part of the problem.

As powerful corporations try to make gambling part of everyday life, it’s important for Arkansas to protect its citizens and families from predatory gambling. Otherwise gambling addiction will simply continue wrecking lives and hurting families in our state.

Articles appearing on this website are written with the aid of Family Council’s researchers and writers.